Antifungal effects of the biological agent Pythium oligandrum observed in vitro

0506819 - GLÚ 2020 RIV GB eng J - Journal Article
Načeradská, M. - Fridrichová, Michaela - Kellnerová, D. - Peková, S. - Lány, P.
Antifungal effects of the biological agent Pythium oligandrum observed in vitro.
Journal of Feline Medicine and Surgery. Roč. 19, č. 8 (2017), s. 817-823. ISSN 1098-612X. E-ISSN 1532-2750
Institutional support: RVO:67985831
Keywords : electron microscopy * scanning * microphotography * Pythium * antifungal activity
OECD category: Optics (including laser optics and quantum optics)
Impact factor: 1.466, year: 2017
Method of publishing: Limited access
https://journals.sagepub.com/doi/10.1177/1098612X16658690

Objectives: Dermatophytosis, commonly known as ringworm, is a superficial fungal skin disease and zoonosis. Pythium oligandrum is a micromycete with mycoparasitic properties that is used in agriculture to control fungal infections on plants. Formulations containing P oligandrum were also developed for the treatment of dermatophytoses, but only a small number of case studies have been published. In order to document the process in simplified conditions in vitro, we investigated the effectiveness of P oligandrum against three pathogenic dermatophytes common in domestic animals. Methods: Cultures of the pathogens grown on nutrient media and experimentally infected cat hair were treated with P oligandrum preparations in therapeutic concentration and the changes were documented by microscopic videos and scanning electron microscopy. Results: There was strong mycoparasitic activity of P oligandrum against Microsporum canis, Microsporum gypseum and Trichophyton mentagrophytes. Conclusions and relevance: P oligandrum was demonstrated to be effective against three common causes of dermatophytosis in vitro.
Permanent Link: http://hdl.handle.net/11104/0297983