Lenalidomide treatment in lower risk myelodysplastic syndromes-The experience of a Czech hematology center. (Positive effect of erythropoietin +/- prednisone addition to lenalidomide in refractory or relapsed patients)

0506807 - ÚMG 2020 RIV GB eng J - Journal Article
Jonasova, A. - Neuwirtová, R. - Polackova, H. - Šišková, M. - Stopka, T. - Cmunt, E. - Belickova, M. - Moudrá, Alena - Minařík, L. - Fuchs, O. - Michalová, K. - Zemanová, Z.
Lenalidomide treatment in lower risk myelodysplastic syndromes-The experience of a Czech hematology center. (Positive effect of erythropoietin +/- prednisone addition to lenalidomide in refractory or relapsed patients).
Leukemia Research. Roč. 69, June (2018), s. 12-17. ISSN 0145-2126. E-ISSN 1873-5835
Institutional support: RVO:68378050
Keywords : Myelodysplastic syndromes * Lenalidomide * Del(5q) aberration * Erythropoietin * Prednisone
OECD category: Cell biology
Impact factor: 2.066, year: 2018
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/abs/pii/S0145212618300778?via%3Dihub

Lenalidomide therapy represents meaningful progress in the treatment of anemic patients with myelodysplastic syndromes with del(5q). We present our initial lenalidomide experience and the positive effect of combining erythropoietin and steroids with lenalidomide in refractory and relapsed patients. We treated by lenalidomide 55 (42 female, 13 male, median age 69) chronically transfused lower risk MDS patients with del(5q) (45) and non-del( 5q) (10). Response, meaning transfusion independence (TI) lasting >= eight weeks, was achieved in 38 (90%) of analyzed patients with del(5q), of whom three achieved TI only by adding erythropoietin +/- prednisone. Another five patients responded well to this combination when their anemia relapsed later during the treatment. In the non-del(5q) group only one patient with RARS-T reached TI. Cytogenetic response was reached in 64% (32% complete, 32% partial response). The TP53 mutation was detected in 7 (18%) patients, four patients progressed to higher grade MDS or acute myeloid leukemia (AML). All seven RAEB-1 patients cleared bone marrow blasts during lenalidomide treatment and reached complete remission (CR), however, three later progressed to higher grade MDS or AML. Lenalidomide represents effective treatment for del(5q) group and combination with prednisone and erythropoietin may be used for non-responders or therapy failures.
Permanent Link: http://hdl.handle.net/11104/0297965