The role of the aromatic ligand in the asymmetric transfer hydrogenation of the C=N bond on Noyori's chiral Ru catalysts

0506703 - MBÚ 2020 RIV GB eng J - Journal Article
Šot, P. - Vilhanová, B. - Pecháček, J. - Václavík, J. - Zápal, Jakub - Kuzma, Marek - Kačer, P.
The role of the aromatic ligand in the asymmetric transfer hydrogenation of the C=N bond on Noyori's chiral Ru catalysts.
Tetrahedron Asymmetry. Roč. 25, 18-19 (2014), s. 1346-1351. ISSN 0957-4166
R&D Projects: GA ČR GAP106/12/1276; GA MŠMT(CZ) LO1509
Institutional support: RVO:61388971
Keywords : tethered ruthenium(ii) catalyst * complexes * ketones
OECD category: Microbiology
Impact factor: 2.155, year: 2014
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S095741661400367X?via%3Dihub

Only four types of dimeric precursors [RuCl2(eta(6)-arene)](2) for the synthesis of Noyori's half sandwich diamine catalysts [RuCl(TsDPEN)(eta(6)-arene)] are commercially available, yet so far no study has tried to systematically evaluate how these systems perform during the asymmetric transfer hydrogenation of various 3,4-dihydroisoquinolines (i.e., the typical substrates for Noyori asymmetric transfer hydrogenation benchmarking). Experiments combined with molecular modeling allowed us to assess their properties and formulate a hypothesis clarifying the difference in enantioselectivity of these systems.
Permanent Link: http://hdl.handle.net/11104/0297899