Phenotypic effects of the Y chromosome are variable and structured in hybrids among house mouse recombinant lines

0506504 - ÚBO 2020 RIV US eng J - Journal Article
Martincová, Iva - Ďureje, Ľudovít - Kreisinger, J. - Macholán, Miloš - Piálek, Jaroslav
Phenotypic effects of the Y chromosome are variable and structured in hybrids among house mouse recombinant lines.
Ecology and Evolution. Roč. 9, č. 10 (2019), s. 6124-6137. ISSN 2045-7758. E-ISSN 2045-7758
R&D Projects: GA ČR GA15-13265S; GA ČR(CZ) GA17-25320S
Institutional support: RVO:68081766 ; RVO:67985904
Keywords : Mus musculus domesticus * Mus musculus musculus * phenotype variation * sperm quality * wild-derived strain * Y-associated effects
OECD category: Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology; Genetics and heredity (medical genetics to be 3) (UZFG-Y)
Impact factor: 2.392, year: 2019
Method of publishing: Open access
http://dx.doi.org/10.1002/ece3.5196

Hybrid zones between divergent populations sieve genomes into blocks that introgress across the zone, and blocks that do not, depending on selection between interacting genes. Consistent with Haldane's rule, the Y chromosome has been considered counterselected and hence not to introgress across the European house mouse hybrid zone. However, recent studies detected massive invasion of M. m. musculus Y chromosomes into M. m. domesticus territory. To understand mechanisms facilitating Y spread, we created 31 recombinant lines from eight wild-derived strains representing four localities within the two mouse subspecies. These lines were reciprocally crossed and resulting F1 hybrid males scored for five phenotypic traits associated with male fitness. Molecular analyses of 51 Y-linked SNPs attributed 50% of genetic variation to differences between the subspecies and 8% to differentiation within both taxa. A striking proportion, 21% (frequencies of sperm head abnormalities) and 42% (frequencies of sperm tail dissociations), of phenotypic variation was explained by geographic Y chromosome variants. Our crossing design allowed this explanatory power to be examined across a hierarchical scale from subspecific to local intrastrain effects. We found that divergence and variation were expressed diversely in different phenotypic traits and varied across the whole hierarchical scale. This finding adds another dimension of complexity to studies of Y introgression not only across the house mouse hybrid zone but potentially also in other contact zones.
Permanent Link: http://hdl.handle.net/11104/0297736