0505516 - ÚEB 2020 RIV US eng J - Journal Article
Rárová, L. - Ncube, B. - Van Staden, J. - Fürst, R. - Strnad, Miroslav - Grúz, Jiří
Identification of Narciclasine as an in Vitro Anti-Inflammatory Component of Cyrtanthus contractus by Correlation-Based Metabolomics.
Journal of Natural Products. Roč. 82, č. 5 (2019), s. 1372-1376. ISSN 0163-3864. E-ISSN 1520-6025
Institutional support: RVO:61389030
Keywords : amaryllidaceae * anti-Inflammatory Component * nanotechnology * gene engineering
OECD category: Organic chemistry
Impact factor: 3.782, year: 2019
Method of publishing: Open access
http://doi.org/10.1021/acs.jnatprod.8b00973

In this study, an extract from the bulbs of Cyrtanthus contractus showed strong anti-inflammatory activity in vitro. The extract was partially separated into 14 fractions and analyzed by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry metabolomics, and the correlation coefficients were calculated between biological activities and metabolite levels. As a result, the top-scoring metabolite narciclasine (1) is proposed as the active principle of C. contractus. This was confirmed by comparing the biological effect of crude extract with that of an authentic standard.
Permanent Link: http://hdl.handle.net/11104/0296997