No effect of riluzole and memantine on learning deficit following quinpirole sensitization - An animal model of obsessive-compulsive disorder

0504884 - FGÚ 2020 RIV US eng J - Journal Article
Janíková, Martina - Brožka, Hana - Radostová, Dominika - Svoboda, Jan - Stuchlík, Aleš
No effect of riluzole and memantine on learning deficit following quinpirole sensitization - An animal model of obsessive-compulsive disorder.
Physiology and Behavior. Roč. 204, May 15 (2019), s. 241-247. ISSN 0031-9384. E-ISSN 1873-507X
R&D Projects: GA ČR(CZ) GA17-04047S; GA MZd(CZ) NV15-34524A
Institutional support: RVO:67985823
Keywords : Quinpirole * Memantine * Riluzole * obsessive-compulsive disorder * active allothetic place avoidance task
OECD category: Neurosciences (including psychophysiology
Impact factor: 2.826, year: 2019
Method of publishing: Limited access
https://doi.org/10.1016/j.physbeh.2019.01.013

Rationale:Chronic quinpirole (QNP) sensitization is an established animal model relevant to obsessive-compulsive disorder (OCD) that has been previously shown to induce several OCD-like behavioral patterns, such as compulsive-like checking and increased locomotion.Objectives:In current study we explored the effect of antiglutamatergic drugs, memantine and riluzole, on cognitive and behavioral performance of QNP sensitized rats.Methods:During habituation phase, the rats (N = 56) were injected with QNP (0.25 mg/kg) or saline solution (every other day up to 10 injections) and placed into rotating arena without foot shocks for 50-min exploration. Active place avoidance task in rotating arena with unmarked to-be-avoided shock sector was used during acquisition phase. Rats were injected with memantine (1 mg/kg or 5 mg/kg), riluzole (1 mg/kg or 5 mg/kg) or saline solution 30 min before the trial and with QNP (0.25 mg/kg) or saline right before they were placed inside the rotating arena with 60° unmarked shock sector. Locomotion and number of entrances into the shock sector were recorded.Results:QNP sensitization led to a robust deficit in place learning. However, neither memantine nor riluzole did reverse or alleviate the deficit induced by QNP. Contrarily, memantine significantly aggravated QNP induced deficit.Conclusions:The exacerbation of cognitive deficit following antiglutamatergic agents could be mediated by decreased glutamate concentration in nucleus accumbens and decreased hippocampal activation in the QNP sensitization model.
Permanent Link: http://hdl.handle.net/11104/0296427