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The Role of Tyrosine Oxidation in Structures and Properties of Neurodegenerative Peptides and Proteins
- 1.0504590 - ÚOCHB 2020 RIV JP eng C - Conference Paper (international conference)
Niederhafner, Petr - Brichtová, Eva - Šafařík, Martin - Kiederling, T. A. - Šebestík, Jaroslav
The Role of Tyrosine Oxidation in Structures and Properties of Neurodegenerative Peptides and Proteins.
Peptide Science 2018: Proceedings of the 10th International Peptide Symposium / the 55th Japanese Peptide Symposium. Osaka: Japanese Peptide Society, 2019 - (Futaki, S.; Matsuzaki, K.), s. 59-60. ISBN 978-4-931541-191. ISSN 1344-7661.
[International Peptide Symposium /10./ and Japanese Peptide Symposium /55./. Kyoto (JP), 03.12.2018-07.12.2018]
R&D Projects: GA ČR(CZ) GA17-00121S; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : chiroptical spectroscopies * protein-protein interactions * tyrosine oxidation
OECD category: Biophysics
Neurodegenerative diseases are influenced by oxidative stress. We selectively synthesized oxidized peptides with 3-nitrotyrosine (Nit), and 3-chlorotyrosine (Cly). We have investigated the influence of these oxidized tyrosines on solubility, hydrophobicity, and structure of alpha-synuclein model peptides.
Permanent Link: http://hdl.handle.net/11104/0296184
Number of the records: 1