Identification of short-chain poly-3-hydroxybutyrates in Saiga horn extracts using LC-MS/MS

0504500 - FGÚ 2020 RIV DE eng J - Journal Article
Pataridis, Statis - Romanov, O. - Mikšík, Ivan
Identification of short-chain poly-3-hydroxybutyrates in Saiga horn extracts using LC-MS/MS.
Journal of Separation Science. Roč. 42, č. 4 (2019), s. 797-808. ISSN 1615-9306. E-ISSN 1615-9314
R&D Projects: GA ČR(CZ) GA17-10832S
Institutional support: RVO:67985823
Keywords : liquid chromatography * polyhydroxybutyrates * Saiga horn * tandem mass spectrometry * traditional Chinese medicine
OECD category: Analytical chemistry
Impact factor: 2.878, year: 2019
Method of publishing: Limited access
https://doi.org/10.1002/jssc.201800910

Saiga horn extracts were analyzed with the goal of obtaining new information about compounds present in it. The purpose of this study is to find synthetic alternatives to Saiga horn extract, which is used in traditional Chinese medicine, by identifying potentially biologically active compounds in the extracts. Using high‐performance liquid chromatography coupled with high‐resolution mass spectrometry, we have been able to identify a series of short‐chain polyhydroxybutyrates in alcoholic extracts of Saiga horn. Optimized high‐performance liquid chromatography coupled with tandem mass spectrometry methods for analysis of short‐chain poly‐3‐hydroxybutyrates were developed and subsequently applied to investigate Saiga horn extract for the presence of these compounds, which might explain its biological actions, particularly for its antipyretic and procoagulant properties.
Permanent Link: http://hdl.handle.net/11104/0296120