Advances in Chemical Biology

0502863 - ÚMG 2019 RIV CZ eng M - Monography Chapter
Chawengsaksophak, Kallayanee - Schuster, Bjorn - Epp, Trevor
Application of small molecular inhibitors for the establishment and maintenance of stem cell pluripotency.
Advances in Chemical Biology. Praha: OPTIO CZ, 2019 - (Bartůněk, P.), s. 20-31. ISBN 978-80-88011-03-3
R&D Projects: GA MŠMT LO1220
Institutional support: RVO:68378050
Keywords : FAM208A * HIV-2 auxiliary protein Vpx * antiretroviral drug
OECD category: Cell biology

Retroviruses are not only equipped with machinery to replicate and propagate themselves, such as viral capsid proteins and reverse transcriptase enzymes, but often also contain auxiliary proteins which can either subvert the cellular machinery of the host towards their survival benefit or alternatively, overcome or otherwise temper the antiviral defensive responses of the infected host. Thus the study of retroviral auxiliary proteins and identification of their cellular targets has provided greater understanding of not only retroviral action but also antiviral immunity. Their discovery has spurned the search for small molecule inhibitors of these proteins and the respective host proteins in which they interact, with the aim to produce new antiviral treatments or to minimize any deleterious side-effects associated with retroviral auxiliary protein expression. Here we discuss some of the auxiliary proteins present in human immunodeficiency virus (HIV) and in particular, discuss the recent discovery of FAM208A as a direct target of the HIV-2 auxiliary protein Vpx.
Permanent Link: http://hdl.handle.net/11104/0294989