Hematological Findings in Non-Treated and gamma-Irradiated Mice Deficient for MIC-1/GDF15

0502505 - BFÚ 2019 RIV CZ eng J - Journal Article
Hofer, Michal - Hoferová, Zuzana - Remšík, Jan - Nováková, M. - Procházková, J. - Fedr, Radek - Kohoutek, J. - Dušek, L. - Hampl, A. - Souček, Karel
Hematological Findings in Non-Treated and gamma-Irradiated Mice Deficient for MIC-1/GDF15.
Physiological Research. Roč. 67, č. 4 (2018), s. 623-636. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GA15-11707S; GA ČR(CZ) GA16-12454S; GA MZd(CZ) NV15-28628A; GA MZd(CZ) NV15-33999A
Institutional support: RVO:68081707
Keywords : tgf-beta superfamily * differentiation factor 15 * factor-binding sites * transcription factors
OECD category: Physiology (including cytology)
Impact factor: 1.701, year: 2018

Several members of the TGF-beta family are known to effectively regulate the fate of hematopoietic progenitor cells in a complex and context-dependent manner. Growth differentiation factor-15 (GDF15) is a divergent member of the TGF-beta family. This stress-induced cytokine has been proposed to possess immunomodulatory functions and its high expression is often associated with progression of a variety of pathological conditions. GDF15 is also induced by chemotherapy and irradiation. Very few fundamental studies have been published regarding the effect of GDF15 in hematopoiesis. In this study, we analyzed the hematological status of untreated and gamma-irradiated mice deficient for GDF15 as a result of genetic knock-out (KO), in order to clarify the regulatory role of GDF15 in hematopoiesis. Significant differences between GDF15 KO mice and their pertinent WT controls were found in the parameters of blood monocyte numbers, blood platelet size, and distribution width, as well as in the values of bone marrow granulocyte/macrophage progenitor cells. Different tendencies of some hematological parameters in the GDF15 KO mice in normal conditions and those under exposure of the mice to ionizing radiation were registered. These findings are discussed in the context of the GDF15 gene function and its lack under conditions of radiation-induced damage.
Permanent Link: http://hdl.handle.net/11104/0294426