Impaired Post-Irradiation Survival of Cyclooxygenase-2-Deficient Mice

0502499 - BFÚ 2019 RIV CZ eng J - Journal Article
Hofer, Michal - Hoferová, Zuzana - Gruzdev, A. - Dušek, L. - Falk, Martin
Impaired Post-Irradiation Survival of Cyclooxygenase-2-Deficient Mice.
Physiological Research. Roč. 67, č. 5 (2018), s. 809-812. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR GBP302/12/G157
Institutional support: RVO:68081707
Keywords : selective inhibitors * irradiated mice * meloxicam * Cyclooxygenase-2
OECD category: Physiology (including cytology)
Impact factor: 1.701, year: 2018

We investigated and evaluated post-irradiation survival in cyclooxygenase-2-deficient (COX-2 KO) mice. Thirty-day survival following exposure of COX-2 KO mice to a lethal dose of 8.5 Gy of gamma-rays was observed to be statistically significantly lower in both males and females, as well as when the sexes were merged, in comparisons with their wild-type counterparts. These findings were related to the previous observations concerning the detrimental influence of the COX-2 genetic disruption on hematopoiesis in sublethally irradiated mice. Deteriorated postirradiation survival of COX-2 KO mice confirmed the previously anticipated conclusion regarding negative influence of the antiinflammatory action of COX-2 deficiency under the conditions of exposure of the animals to ionizing radiation.
Permanent Link: http://hdl.handle.net/11104/0294425