Solvation effects alter the photochemistry of 2-thiocytosine

0501670 - BFÚ 2019 RIV NL eng J - Journal Article
Janicki, M.J. - Szabla, Rafal - Šponer, Jiří - Gora, R.W.
Solvation effects alter the photochemistry of 2-thiocytosine.
Chemical Physics. Roč. 515, NOV 14 2018 (2018), s. 502-508. ISSN 0301-0104. E-ISSN 1873-4421
Institutional support: RVO:68081707
Keywords : excited-state deactivation * perturbation-theory * triplet-state * basis-sets
OECD category: Physical chemistry
Impact factor: 1.822, year: 2018

Radiationless deactivation channels of 2-thiocytosine in aqueous environment are revisited by means of quantum-chemical simulations of excited-state absorption spectra, and investigations of potential energy surfaces of the chromophore clustered with two water molecules using the algebraic diagrammatic construction method to the second-order (ADC(2)), and multireference configuration interaction with single and double excitations (MR-CISD) methods. We argue that interactions of explicit water molecules with thiocarbonyl group might enable water-chromophore electron transfer (WCET) which leads to formation of intersystem crossing that was not considered previously. This is the first example of a WCET process occurring in the triplet manifold of electronic states. This phenomenon might explain nonradiative decay of the triplet state population observed in thiopyrimidines in the absence of molecular oxygen. According to our calculations this WCET process might also entail a subsequent, virtually barrierless, electron-driven proton transfer (EDPT) resulting in the formation of hydroxyl radical which could further participate in photohydration or deamination reactions.
Permanent Link: http://hdl.handle.net/11104/0293674