Striking effect of polymer end-group on C60 nanoparticle formation by high shear vibrational milling with alkyne-functionalized poly(2-oxazoline)s

0500763 - ÚMCH 2020 RIV US eng J - Journal Article
Van Guyse, J. F. R. - de la Rosa, V. R. - Lund, R. - De Bruyne, M. - De Rycke, R. - Filippov, Sergey K. - Hoogenboom, R.
Striking effect of polymer end-group on C60 nanoparticle formation by high shear vibrational milling with alkyne-functionalized poly(2-oxazoline)s.
ACS Macro Letters. Roč. 8, č. 2 (2019), s. 172-176. E-ISSN 2161-1653
Grant - others:AV ČR(CZ) FWO-17-05
Program: Bilaterální spolupráce
Institutional support: RVO:61389013
Keywords : poly(2-oxazoline)s * nanoparticle * fullerene
OECD category: Polymer science
Impact factor: 6.042, year: 2019
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acsmacrolett.8b00998

Buckminsterfullerene (C60) has a large potential for biomedical applications. However, the main challenge for the realization of its biomedical application potential is to overcome its extremely low water solubility. One approach is the coformulation with biocompatible water-soluble polymers, such as poly(2-oxazoline)s (PAOx), to form water-soluble C60 nanoparticles (NPs). However, uniform and defined NPs have only been obtained via a thin film hydration method or using cyclodextrin-functionalized PAOx. Here, we report the mechanochemical preparation of defined and stable C60:PAOx NPs by the introduction of a simple alkyne group as a polymer end-group. The presence of this alkyne bond is proven to be crucial in the mechanochemical synthesis of stable, defined sub-100 nm C60:PAOx NPs, with high C60 content up to 8.9 wt %.
Permanent Link: http://hdl.handle.net/11104/0294173