Effect of the configuration of poly(lactic acid) and content of poly(oxyethylene) blocks to the structure and functional properties of poly(lactic acid)‐block‐poly(oxirane)‐based nanofibrous electrospun polyester-ether-urethanes used as potential drug‐delivery system

0500688 - ÚH 2020 RIV US eng J - Journal Article
Pavelková, A. - Kucharczyk, P. - Capáková, Z. - Peer, Petra - Pummerová, M. - Zedník, J. - Vohlídal, J. - Sedlařík, V.
Effect of the configuration of poly(lactic acid) and content of poly(oxyethylene) blocks to the structure and functional properties of poly(lactic acid)‐block‐poly(oxirane)‐based nanofibrous electrospun polyester-ether-urethanes used as potential drug‐delivery system.
Journal of Biomedical Materials Research. Part B. Roč. 107, č. 7 (2019), s. 2378-2387. ISSN 1552-4973. E-ISSN 1552-4981
R&D Projects: GA ČR(CZ) GJ15-08287Y; GA MŠMT ED2.1.00/19.0409
Grant - others:Ministerstvo školství, mládeže a tělovýchovy (MŠMT)(CZ) LO1504
Institutional support: RVO:67985874
Keywords : poly(lactic acid) * polyester-urethanes * electrospinning * drug delivery * abiotic * degradation * nanofibers * vancomycin
OECD category: Polymer science
Impact factor: 2.831, year: 2019
Method of publishing: Limited access
https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.b.34331

Poly(lactic acid)‐block‐poly(oxirane)s (PLA‐b‐POE) of various compositions were prepared using a one‐pot approach and then extended in a reaction with l‐lysine diethyl ester diisocyanate, thereby forming polyester–ether–urethanes (PEU) with prolonged chains and units with increased degradability. The PEUs are processed by electrospinning to prepare degradable nanofibrous sheet materials with and without encapsulating the antibiotic Vancomycin (VAC). PLA block isomerism and POE blocks oligomeric content (1000 g/mol) affect the thermal properties, processability, nanofibrous sheet morphology, abiotic degradation, cytocompatibility, and encapsulated antibiotic release rate of prepared PEUs. Therefore, our findings provide an effective approach to tuning the functional properties of these advanced biocompatible materials.
Permanent Link: http://hdl.handle.net/11104/0299559