0500637 - ÚI 2019 US eng J - Journal Article
Dolejšová, O. - Kučera, R. - Fuchsová, R. - Topolčan, O. - Svobodová, H. - Hes, O. - Eret, V. - Pecen, Ladislav - Hora, M.
The Ability of Prostate Health Index (PHI) to Predict Gleason Score in Patients With Prostate Cancer and Discriminate Patients Between Gleason Score 6 and Gleason Score Higher Than 6-A Study on 320 Patients After Radical Prostatectomy.
Technology in Cancer Research & Treatment. Roč. 17, 18 July (2018), s. 1-6. ISSN 1533-0346. E-ISSN 1533-0338
Keywords : pathologically favorable disease * antigen isoform * identification * percent-p2psa * derivatives * p2psa * prostate health index * prostate-specific antigen * prostate cancer * Gleason score * prostate biopsy * radical prostatectomy
Impact factor: 1.481, year: 2018

Aim: The purpose of this study was to investigate the Prostate Health Index as a marker for tumor aggressiveness in prostate biopsy and the optimization of indication for treatment options. Methods: Our cohort consisted of 320 patients indicated for radical prostatectomy with preoperative measurements of total prostate-specific antigen, free prostate-specific antigen, [-2] proPSA, calculated %freePSA, and Prostate Health Index. The Gleason score was determined during biopsy and after radical prostatectomy. Using the Gleason score, we divided the group of patients into the 2 subgroups: Gleason score <= 6 and Gleason score >6. This division was performed according to the biopsy Gleason score and according to the postoperative Gleason score. We compared total prostates-pecific antigen, [-2] proPSA,%freePSA, and Prostate Health Index in the subgroups Gleason score <= 6 and Gleason score >6 after biopsy and the definitive score. Results: On evaluation of the subgroups created by Gleason score <= 6 and Gleason score >6, we observed agreement between biopsy Gleason score and definitive Gleason score in only 45.3% of cases. Of the calculated biopsy, Gleason score <= 6 and Gleason score >6 subgroups, [-2] proPSA, and Prostate Health Index (P = .0003 and P = .0005) were statistically significant. Of the definitive Gleason score <= 6 and Gleason score >6 subgroups, Prostate Health Index, [-2] proPSA, %freePSA, and PSA (P < .0001, P < .0001, P = .0003, and P = .0043) were statistically significant. The best area under the curve value (0.7496) was achieved by Prostate Health Index when the subgroups were established according to the postoperative Gleason score. Conclusion: Prostate Health Index is the best of the tested markers for the categorization of Gleason score 6 tumors and for facilitating the management of patients with prostate cancer. Prostate Health Index can be a helpful marker for indication of active surveillance or radical prostatectomy. Prostate health index can also simplify the decision of whether to perform nerve-sparing radical prostatectomy.
Permanent Link: http://hdl.handle.net/11104/0292722