神経保護特性を有する両親媒性化合物

0500385 - ÚOCHB 2019 RIV jpn P - Patent Document
Kudová, Eva - Chodounská, Hana - Kapras, Vojtěch - Vyklický ml., Ladislav - Valeš, Karel - Jahn, Ullrich
神経保護特性を有する両親媒性化合物.
[Amphiphilic compounds with neuroprotective properties.]
2018. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. - Fyziologický ústav AV ČR, v. v. i. Date of the patent acceptance: 22.11.2018. Patent Number: JP6437636
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GBP304/12/G069
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : steroid * NMDA receptor * neuroprotective
OECD category: Organic chemistry; Pharmacology and pharmacy (FGU-C)
https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20181212&DB=&locale=en_EP&CC=JP&NR=6437636B2&KC=B2&ND=4#

本発明は、神経保護効果を示す、テトラデカヒドロフェナントレン骨格を有する両親媒性化合物およびそれらのエナンチオマー、ＣＮＳの虚血性損傷、ＣＮＳの神経変性および障害などのグルタミン酸作動性神経伝達物質系の不均衡に関連する神経精神障害の治療薬としての使用、うつ病、心的外傷後ストレス障害およびストレスに関連する疾患、不安、統合失調症および精神病性障害、疼痛、中毒、多発性硬化症、てんかん、神経膠腫、ならびに前記化合物を含有する医薬組成物。

The present invention provides amphiphilic compounds with tetradecahydrophenanthrene skeleton and their enantiomers, exhibiting neuroprotective effects, their use as medicaments for treating neuropsychiatric disorders associated with an imbalance in glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post-traumatic stress disorder and diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain, addiction, multiple sclerosis, epilepsy, glioma, and a pharmaceutical composition containing said compound.
Permanent Link: http://hdl.handle.net/11104/0293144