Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development

0500373 - ÚMG 2019 RIV CH eng J - Journal Article
Procházková, Michaela - Procházka, Jan - Marangoni, P. - Klein, O. D.
Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development.
Frontiers in genetics. Roč. 9, November (2018), č. článku 542. E-ISSN 1664-8021
R&D Projects: GA MŠMT(CZ) LM2015040; GA MŠMT ED2.1.00/19.0395
Grant - others:GA MŠk(CZ) CZ.1.05/1.1.00/02.0109
Institutional support: RVO:68378050
Keywords : fgf10 * craniofacial development * palate * salivary gland * lacrimal gland * inner ear * eyelid * taste papillae
OECD category: Developmental biology
Impact factor: 3.517, year: 2018

Members of the fibroblast growth factor (FGF) family have myriad functions during development of both non-vertebrate and vertebrate organisms. One of these family members, FGF10, is largely expressed in mesenchymal tissues and is essential for postnatal life because of its critical role in development of the craniofacial complex, as well as in lung branching. Here, we review the function of FGF10 in morphogenesis of craniofacial organs. Genetic mouse models have demonstrated that the dysregulation or absence of FGF10 function affects the process of palate closure, and FGF10 is also required for development of salivary and lacrimal glands, the inner ear, eye lids, tongue taste papillae, teeth, and skull bones. Importantly, mutations within the FGF10 locus have been described in connection with craniofacial malformations in humans. A detailed understanding of craniofacial defects caused by dysregulation of FGF10 and the precise mechanisms that underlie them offers new opportunities for development of medical treatments for patients with birth defects and for regenerative approaches for cancer patients with damaged gland tissues.
Permanent Link: http://hdl.handle.net/11104/0292457