Physicochemical characterization and antioxidant properties of cerium oxide nanoparticles

0500059 - ÚFM 2021 RIV GB eng C - Conference Paper (international conference)
Vazirov, R.A. - Sokovnin, S. Y. - Ilves, V. G. - Bazhukova, I. N. - Pizúrová, Naděžda - Kuznetsov, M. V.
Physicochemical characterization and antioxidant properties of cerium oxide nanoparticles.
Journal of Physics: Conference Series. Vol. 1115. Bristol: Institute of Physics Publishing, 2018 - (Sorokin, D.; Vorobyov, M.), č. článku 032094. ISSN 1742-6588.
[EFRE 2018 - International Congress on Energy Fluxes and Radiation Effects 2018 /6./. Tomsk (RU), 16.09.2018-22.09.2018]
Institutional support: RVO:68081723
Keywords : Alkalinity * Antioxidants * Bioactivity * Chemical analysis
OECD category: Nano-materials (production and properties)

Studies of the biological activity of cerium oxide nanoparticles (CONPs) show that this compound exhibits antioxidant, antitumor, antibacterial and antiviral properties. The CONPs were obtained by pulsed electron evaporation in a low-pressure gas with a specific surface area of ∼ 190 m2/g. Strongly-noequilibrium conditions of synthesis led to the formation of high defect structures, which makes it possible to change the Ce3+/Ce4+ions ratio and, consequently, to enhance the level of their biological activity. To analyze the content of cerium with different valences, X-ray photoelectron spectroscopy was performed. To determine the enzyme-like activity of CONPs, a chemical analysis of the interaction with hydrogen peroxide was carried out on a spectrophotometer. The results show a significant presence of Ce3+in CONPs and the inhibition of reactive oxygen species (ROS). The valence of the cerium atoms determines the chemical activity of CONPs, thus, in a more alkaline medium, the CONPs decrease the ROS concentration, while in the acidic medium its activity diminishes. By varying the parameters of the nanopowders obtained and achieving the optimum Ce3+/Ce4+ ratio, one can produce CONPs having properties which enable the creation of pharmaceuticals for protection against ROS or for combating tumors, viruses and bacteria
Permanent Link: http://hdl.handle.net/11104/0301447