Insulin derivative with cyclic structure in the C-terminus of the B-chain

0499715 - ÚOCHB 2019 RIV eng P - Patent Document
Jiráček, Jiří - Žáková, Lenka - Vaněk, Václav - Veverka, Václav - Brzozowski, A. M.
Insulin derivative with cyclic structure in the C-terminus of the B-chain.
2018. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. - The University of York. Date of the patent acceptance: 27.06.2018. Patent Number: EP3160993
Institutional support: RVO:61388963
Keywords : insulin receptor * agonism * diabetes * insulin analogue
OECD category: Biochemistry and molecular biology
https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=EP&NR=3160993B1&KC=B1&FT=D&ND=4&date=20180627&DB=&locale=en_EP#

The present invention relates to an insulin derivative of formula I, consisting of des(B23-B30)octapeptide-insulin (DOI) and a modified octapeptide, which form an amide bond between the carboxyl group of C-terminal ArgB22 in the DOI molecule and the amino group of N-terminal GlyB23 in the molecule of the modified octapeptide comprising a cyclic structure. The des(B23-B30)octapeptide-insulin is human insulin without the C-terminal octapeptide B23-30 and the modified octapeptide imitates the B23-B30 sequence of human insulin. The insulin derivative of formula I is suitable for use as an anti-diabetic agent with a fast onset of action and low risk of cancer propagation.
Permanent Link: http://hdl.handle.net/11104/0291926