5-substituted 7-[4-(2-pyridyl)phenylmethylamino]-3-iso propylpyrazolo[4,3-d]pyrimidine derivatives, use thereof as medicaments and pharmaceutical compositions

0499696 - ÚEB 2020 RIV eng P - Patent Document
Havlíček, Libor - Šturc, Antonín - Kryštof, Vladimír - Jorda, Radek - Pospíšil, Tomáš - Zahler, S. - Vollmar, A. - Strnad, Miroslav
5-substituted 7-[4-(2-pyridyl)phenylmethylamino]-3-iso propylpyrazolo[4,3-d]pyrimidine derivatives, use thereof as medicaments and pharmaceutical compositions.
2019. Owner: Ústav experimentální botaniky AV ČR, v. v. i. – Palackého Univerzita v Olomouci. Date of the patent acceptance: 01.05.2019. Patent Number: EP3294741
R&D Projects: GA TA ČR(CZ) TG03010009
Institutional support: RVO:61389030
Keywords : cyclin-dependent kinases inhibitor * pharmaceutical preparation * apoptosis
OECD category: Organic chemistry
https://patentimages.storage.googleapis.com/3f/cc/70/2c1c8da7701523/EP3294741B1.pdf

The present invention relates to novel 5-substituted-7-[4-(2-pyridyl) phenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidines of formula I which are potent inhibitors of protein kinases, especially cyclin- dependerit kinases such as CDK2 and CDK5, and display antileukemic, pro-apoptotic, antiangiogenic and anticancer activities. The invention also relates to processes for their preparation, to pharmaceutical compositions comprising them and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation, apoptosis, angiogenesis and inflammation, such as leukemia and metastatic solid cancer.
Permanent Link: http://hdl.handle.net/11104/0291917