PRIMIN DERIVATIVES, METHOD OF PREPARATION THEREOF AND USE THEREOF

0499587 - ÚEB 2019 RIV eng P - Patent Document
Landa, Přemysl - Šíša, Miroslav - Vaněk, Tomáš - Rárová, Lucie
PRIMIN DERIVATIVES, METHOD OF PREPARATION THEREOF AND USE THEREOF.
2018. Owner: Ústav experimentální botaniky AV ČR, v. v. i. Date of the patent acceptance: 19.12.2018. Patent Number: ZA2017/08339
Institutional support: RVO:61389030
Keywords : primin derivatives * Anti-inflammatory activity * pharmaceutical industry
OECD category: Organic chemistry
https://patentsearch.cipc.co.za/patents/patdetails.aspx?data=oXc%2bbAUVDnkljcXGVvMYJInzt4ORl9PsUIjgtDCYTDDBQIybCiTb8aYVHmyPy5JjmE2ZpsfiByCZHGUPJFyJ4AOTK5JBmzoHRhPC31t8njkLUwHB%2bsZhkpD0ye82P4mq

The present invention provides primin derivatives of general formula II and/or III, wherein R1 is selected from the group consisting of methyl and hydrogen, R2 is selected from the group consisting of methoxy, hydroxy, hydrogen, R3 is selected from the group consisting of bromine atom, n-(CH2)nCH3, n-(CH2)nCH2-OH, n-(CH2)nCH2-NH2, wherein n=1 to 16, X is selected from the group consisting of: hydroxy, amino in formula II, keto, imino in formula III, Y is selected from the group consisting of hydrogen, hydroxy in formula II, keto in formula III, whereas, when X and Y are keto groups (in formula III) or hydroxy groups (in formula II), R3 is pentyl and R1 is methyl, then R2 is not hydrogen. These derivatives are suitable for use as anti-inflammatory, pain-relieving and asthma-relieving agents.
Permanent Link: http://hdl.handle.net/11104/0291801