Number of the records: 1  

A bite so sweet: the glycobiology interface of tick-host-pathogen interactions

  1. 1.
    0498840 - BC 2019 RIV GB eng J - Journal Article
    Věchtová, Pavlína - Štěrbová, Jarmila - Štěrba, Ján - Vancová, Marie - Rego, Ryan O. M. - Selinger, Martin - Strnad, Martin - Golovchenko, Maryna - Rudenko, Natalia - Grubhoffer, Libor
    A bite so sweet: the glycobiology interface of tick-host-pathogen interactions.
    Parasites & Vectors. Roč. 11, č. 1 (2018), č. článku 594. ISSN 1756-3305. E-ISSN 1756-3305
    R&D Projects: GA MŠMT(CZ) EE2.3.30.0032; GA MŠMT(CZ) LM2015062; GA ČR(CZ) GA15-03044S; GA MŠMT(CZ) LTARF18021
    EU Projects: European Commission(XE) 602272 - ANTIDotE; European Commission(XE) 278976 - ANTIGONE
    Institutional support: RVO:60077344
    Keywords : Borrelia * Anaplasma * Glycan * Glycobiology * Host * Lectin * Pathogen * tbev * Tick * Carbohydrate-binding
    OECD category: Microbiology
    Impact factor: 3.031, year: 2018
    Method of publishing: Open access
    https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-018-3062-7

    Vector-borne diseases constitute 17% of all infectious diseases in the world, among the blood-feeding arthropods, ticks transmit the highest number of pathogens. Understanding the interactions between the tick vector, the mammalian host and the pathogens circulating between them is the basis for the successful development of vaccines against ticks or the tick-transmitted pathogens as well as for the development of specific treatments against tick-borne infections. A lot of effort has been put into transcriptomic and proteomic analyses, however, the protein-carbohydrate interactions and the overall glycobiology of ticks and tick-borne pathogens has not been given the importance or priority deserved. Novel (bio)analytical techniques and their availability have immensely increased the possibilities in glycobiology research and thus novel information in the glycobiology of ticks and tick-borne pathogens is being generated at a faster pace each year. This review brings a comprehensive summary of the knowledge on both the glycosylated proteins and the glycan-binding proteins of the ticks as well as the tick-transmitted pathogens, with emphasis on the interactions allowing the infection of both the ticks and the hosts by various bacteria and tick-borne encephalitis virus.
    Permanent Link: http://hdl.handle.net/11104/0291110

     
     
Number of the records: 1  

  This site uses cookies to make them easier to browse. Learn more about how we use cookies.