Fe–S cluster assembly in the supergroup Excavata

0498794 - BC 2019 RIV DE eng J - Journal Article
Peña-Diaz, Priscila - Lukeš, Julius
Fe–S cluster assembly in the supergroup Excavata.
Journal of Biological Inorganic Chemistry. Roč. 23, č. 4 (2018), s. 521-541. ISSN 0949-8257. E-ISSN 1432-1327
R&D Projects: GA ČR(CZ) GA16-18699S; GA MŠMT LL1601; GA MŠMT(CZ) EF16_019/0000759
Grant - others:COST (European Cooperation in Science and Technology)(BE) COST Action CA15133
Program: The Biogenesis of Iron-sulfur Proteins: from Cellular Biology to Molecular Aspects (FeSBioNet)
Institutional support: RVO:60077344
Keywords : Evolution * Excavata * Fe–S cluster * Mitochondria
OECD category: Genetics and heredity (medical genetics to be 3)
Impact factor: 3.632, year: 2018
Method of publishing: Open access

The majority of established model organisms belong to the supergroup Opisthokonta, which includes yeasts and animals. While enlightening, this focus has neglected protists, organisms that represent the bulk of eukaryotic diversity and are often regarded as primitive eukaryotes. One of these is the “supergroup” Excavata, which comprises unicellular flagellates of diverse lifestyles and contains species of medical importance, such as Trichomonas, Giardia, Naegleria, Trypanosoma and Leishmania. Excavata exhibits a continuum in mitochondrial forms, ranging from classical aerobic, cristae-bearing mitochondria to mitochondria-related organelles, such as hydrogenosomes and mitosomes, to the extreme case of a complete absence of the organelle. All forms of mitochondria house a machinery for the assembly of Fe–S clusters, ancient cofactors required in various biochemical activities needed to sustain every extant cell. In this review, we survey what is known about the Fe–S cluster assembly in the supergroup Excavata. We aim to bring attention to the diversity found in this group, reflected in gene losses and gains that have shaped the Fe–S cluster biogenesis pathways.
Permanent Link: http://hdl.handle.net/11104/0291070