Contrasting maternal and paternal genetic variation of hunter-gatherer groups in Thailand

0498722 - BC 2019 RIV GB eng J - Journal Article
Kutanan, W. - Kampuansai, J. - Changmai, P. - Flegontov, Pavel - Schröder, R. - MacHoldt, E. - Hübner, A. - Kangwanpong, D. - Stoneking, M.
Contrasting maternal and paternal genetic variation of hunter-gatherer groups in Thailand.
Scientific Reports. Roč. 8, JAN 24 (2018), č. článku 1536. ISSN 2045-2322. E-ISSN 2045-2322
Institutional support: RVO:60077344
Keywords : MITOCHONDRIAL GENOME VARIATION * Y-CHROMOSOME DIVERSITY * SOUTHEAST-ASIA * EVOLUTIONARY HISTORY * ANDAMAN ISLANDS * SEQUENCING DATA * MTDNA GENOMES * NEW-GUINEA
OECD category: Microbiology
Impact factor: 4.011, year: 2018
https://www.nature.com/articles/s41598-018-20020-0

The Maniq and Mlabri are the only recorded nomadic hunter-gatherer groups in Thailand. Here, we sequenced complete mitochondrial (mt) DNA genomes and ~2.364 Mbp of non-recombining Y chromosome (NRY) to learn more about the origins of these two enigmatic populations. Both groups exhibited low genetic diversity compared to other Thai populations, and contrasting patterns of mtDNA and NRY diversity: There was greater mtDNA diversity in the Maniq than in the Mlabri, while the converse was true for the NRY. We found basal uniparental lineages in the Maniq, namely mtDNA haplogroups M21a, R21 and M17a, and NRY haplogroup K. Overall, the Maniq are genetically similar to other negrito groups in Southeast Asia. By contrast, the Mlabri haplogroups (B5a1b1 for mtDNA and O1b1a1a1b and O1b1a1a1b1a1 for the NRY) are common lineages in Southeast Asian non-negrito groups, and overall the Mlabri are genetically similar to their linguistic relatives (Htin and Khmu) and other groups from northeastern Thailand. In agreement with previous studies of the Mlabri, our results indicate that the Malbri do not directly descend from the indigenous negritos. Instead, they likely have a recent origin (within the past 1,000 years) by an extreme founder event (involving just one maternal and two paternal lineages) from an agricultural group, most likely the Htin or a closely-related group.
Permanent Link: http://hdl.handle.net/11104/0291004