Membrane Lipid Nanodomains

0498437 - ÚFCH JH 2019 RIV US eng J - Journal Article
Cebecauer, Marek - Amaro, Mariana - Jurkiewicz, Piotr - Sarmento, Maria Joäo - Šachl, Radek - Cwiklik, Lukasz - Hof, Martin
Membrane Lipid Nanodomains.
Chemical Reviews. Roč. 118, č. 23 (2018), s. 11259-11297. ISSN 0009-2665. E-ISSN 1520-6890
R&D Projects: GA ČR GA17-03160S
Institutional support: RVO:61388955
Keywords : membranes * nanomaterials * lipids
OECD category: Physical chemistry
Impact factor: 54.301, year: 2018

Lipid membranes can spontaneously organize their components into domains of different sizes and properties. The organization of membrane lipids into nanodomains might potentially play a role in vital functions of cells and organisms. Model membranes represent attractive systems to study lipid nanodomains, which cannot be directly addressed in living cells with the currently available methods. This review summarizes the knowledge on lipid nanodomains in model membranes and exposes how their specific character contrasts with large-scale phase separation. The overview on lipid nanodomains in membranes composed of diverse lipids (e.g., zwitterionic and anionic glycerophospholipids, ceramides, glycosphingolipids) and cholesterol aims to evidence the impact of chemical, electrostatic, and geometric properties of lipids on nanodomain formation. Furthermore, the effects of curvature, asymmetry, and ions on membrane nanodomains are shown to be highly relevant aspects that may also modulate lipid nanodomains in cellular membranes. Potential mechanisms responsible for the formation and dynamics of nanodomains are discussed with support from available theories and computational studies. A brief description of current fluorescence techniques and analytical tools that enabled progress in lipid nanodomain studies is also included. Further directions are proposed to successfully extend this research to cells.
Permanent Link: http://hdl.handle.net/11104/0290809