Analysis of proteomic changes in human breast carcinoma MDA-MB-231 cells induced by tributyltin isothiocyanate, the biologically active ligand of nuclear retinoid X receptors

0497021 - ÚIACH 2019 eng A - Abstract
Brtko, J. - Strouhalová, Dana - Toporová, L. - Macejová, D. - Bobál, P. - Otevřel, J. - Bobálová, Janette
Analysis of proteomic changes in human breast carcinoma MDA-MB-231 cells induced by tributyltin isothiocyanate, the biologically active ligand of nuclear retinoid X receptors.
2018 NCRI Cancer Conference. National Cancer Research Institute, 2018.
[2018 NCRI Cancer Conference. 04.11.2018-06.11.2018, Glasgow]
Grant - others:AV ČR(CZ) SAV-18-16
Program: Bilaterální spolupráce
Institutional support: RVO:68081715
Keywords : tributyltin isothiocyanate * nuclear retinoid X receptors * proteomic analysis
OECD category: Analytical chemistry

Our data on combined eitea of aI/-trans retinoic acid and tributyltin isothiocyanate based on proteomic analysis provide new insights into a
role of RXR/RARheterodimer. The knowledge achieved from current study offers further opportunlty to study triorganotins more intensively
in order to enhanee antltumor effeet of naturel or synthetie RARsligands and also take advantage of the faet on direet aetivation of RXRby
triorganotins.

Permanent Link: http://hdl.handle.net/11104/0289633