MiR-126 in intestinal-type sinonasal adenocarcinomas: exosomal transfer of MiR-126 promotes anti-tumour responses

0496022 - BTÚ 2019 RIV GB eng J - Journal Article
Tomasetti, M. - Re, M. - Monaco, F. - Gaetani, S. - Rubini, C. - Bertini, A. - Pasquini, E. - Bersaglieri, C. - Bracci, M. - Staffolani, S. - Colomba, M. - Gregorini, A. - Valentino, M. - Tagliabracci, A. - Bovenzi, M. - Neužil, Jiří - Amati, M. - Santarelli, L.
MiR-126 in intestinal-type sinonasal adenocarcinomas: exosomal transfer of MiR-126 promotes anti-tumour responses.
Bmc Cancer. Roč. 18, SEP 17 2018 (2018), č. článku 896. E-ISSN 1471-2407
R&D Projects: GA MZd(CZ) NV16-31604A
Keywords : Intestinal-type sinonasal adenocarcinomas * Inflammatory polyps * Sinonasal-inverted papillomas
OECD category: Oncology
Impact factor: 2.933, year: 2018

Background: Intestinal-type sinonasal adenocarcinomas (ITACs) are aggressive malignancies related to wood dust and leather exposure. ITACs are generally associated with advanced stage at presentation due to the insidious growth pattern and non-specific symptoms. Therefore, biomarkers that can detect the switch from the benign disease to malignancy are needed. Essential for tumour growth, angiogenesis is an important step in tumour development and progression. This process is strictly regulated, and MiR-126 considered its master modulator.
Permanent Link: http://hdl.handle.net/11104/0288867