Study of blood clotting mechanism by rheological, electrorheological and AFM methods

0495931 - ÚH 2019 RIV eng A - Abstract
Antonova, N. - Říha, Pavel - Ivanov, I. - Alexandrova, A.
Study of blood clotting mechanism by rheological, electrorheological and AFM methods.
2018.
[Eurosummer School on Biorheology & Symposium on Micro and Nano Mechanics and Mechanobiology of Cells, Tissues and Systems /6./. 29.08.2018-01.09.2018, Varna]
Institutional research plan: CEZ:AV0Z20600510
Institutional support: RVO:67985874
Keywords : thrombus formation in vitro * viscosity and viscoelasticity of blood clot * electrorheological method * kinetics of clot formation * atomic force microscopy
OECD category: Medical laboratory technology (including laboratory samples analysis

A comparative study of the mechanical properties of the in vitro induced blood clot by means of rheological electrorheological methods and atomic force microscopy (AFM) is presented. Dynamic viscosity data and viscoelasticity of blood clots, induced in vitro have been determined. The kinetics of clot formation was measured and analysed in parallel with changes of the conductivity of the forming clot, estimated by electrorheological method. The results were analyzed in parallel with images of morphological characteristics of thrombus obtained using AFM: 2D and 3D topography of the clot.
Permanent Link: http://hdl.handle.net/11104/0292647