Newborn foal with atypical myopathy

0495766 - ÚEB 2019 RIV US eng J - Journal Article
Karlíková, H. - Široká, Jitka - Mech, M. - Friedecký, D. - Janečková, H. - Mádrová, L. - Hrdinová, J. - Drábková, Z. - Dobešová, J. - Adam, T. - Jahn, P.
Newborn foal with atypical myopathy.
Journal of Veterinary Internal Medicine. Roč. 32, č. 5 (2018), s. 1768-1772. ISSN 0891-6640. E-ISSN 1939-1676
R&D Projects: GA MŠMT(CZ) LO1304
Institutional support: RVO:61389030
Keywords : acyl-coa dehydrogenase * acer-pseudoplatanus * hypoglycin * horses * acid * inactivation * intoxication * deficiency * metabolism * placenta * acylcarnitines * hypoglycin A * metabolomics * methylenecyclopropyl acetyl carnitine * multiple acyl-coenzyme A dehydrogenase deficiency
OECD category: Other clinical medicine subjects
Impact factor: 2.286, year: 2018

The case of atypical myopathy (AM) in newborn Haflinger foal with clinical signs of depression and weakness appearing 6 hours after birth resulting in recumbency 12 hours after birth is described. The foal's dam was diagnosed with AM in the 6th month of gestation based on clinical signs of a myopathy, elevated serum activity of creatine kinase, metabolomic analysis and the presence of methylenecyclopropyl acetyl carnitine (MCPA-carnitine) in the blood. At the time of delivery, the mare was grazing on a pasture near sycamore trees but was free of clinical signs of AM. Metabolomic analysis of the foal's blood revealed increased concentrations of acylcarnitines and MCPA-carnitine consistent with metabolic profiles of blood from AM affected horses. Two theories could explain this observation (a) hypoglycin A or its metabolites accumulated in the mare's placenta with consequent transfer to fetus or (b) these compounds were secreted into mare's milk.
Permanent Link: http://hdl.handle.net/11104/0288687