MPO (Myeloperoxidase) Reduces Endothelial Glycocalyx Thickness Dependent on Its Cationic Charge

0495517 - BFÚ 2019 RIV US eng J - Journal Article
Manchanda, K. - Kolářová, Hana - Kerkenpass, Ch. - Mollenhauer, M. - Víteček, Jan - Rudolph, R. - Kubala, Lukáš - Baldus, S. - Adam, M. - Klinke, A.
MPO (Myeloperoxidase) Reduces Endothelial Glycocalyx Thickness Dependent on Its Cationic Charge.
Arteriosclerosis Thrombosis and Vascular Biology. Roč. 38, č. 8 (2018), s. 1859-1867. ISSN 1079-5642. E-ISSN 1524-4636
Institutional support: RVO:68081707
Keywords : surface-layer * in-vivo * integrin activation * vascular-disease * leukocyte * capillary * neutrophils * proteins * adhesion * barrier
OECD category: Biochemistry and molecular biology
Impact factor: 6.618, year: 2018

Objective The leukocyte heme-enzyme MPO (myeloperoxidase) exerts proinflammatory effects on the vascular system primarily linked to its catalytic properties. Recent studies have shown that MPO, depending on its cationic charge, mediates neutrophil recruitment and activation. Here, we further investigated MPO's extracatalytic properties and its effect on endothelial glycocalyx (EG) integrity.
Permanent Link: http://hdl.handle.net/11104/0288483