A new microcystin producing Nostoc strain discovered in broad toxicological screening of non-planktic Nostocaceae (cyanobacteria)

0495227 - BC 2019 RIV GB eng J - Journal Article
Kust, Andreja - Urajová, P. - Hrouzek, P. - Vu, D.L. - Čapková, Kateřina - Štenclová, Lenka - Řeháková, Klára - Kozlíková-Zapomělová, Eliška - Lepšová-Skácelová, O. - Lukešová, Alena - Mareš, Jan
A new microcystin producing Nostoc strain discovered in broad toxicological screening of non-planktic Nostocaceae (cyanobacteria).
Toxicon. Roč. 150, AUG (2018), s. 66-73. ISSN 0041-0101. E-ISSN 1879-3150
R&D Projects: GA ČR(CZ) GA14-18067S
Institutional support: RVO:60077344
Keywords : Anabaena * Cyanotoxins * Heterocytous cyanobacteria * Microcystin * Non-planktic Nostocaceae
OECD category: Microbiology
Impact factor: 2.276, year: 2018

Benthic cyanobacteria recognized as producers of natural products, including cyanotoxins, have been neglected for systematic toxicological studies. Thus, we have performed a broad study investigating cyanotoxin potential of 311 non-planktic nostocacean representatives combining molecular and chemical analyses. Out of these, a single strain Nostoc sp. Treb K1/5, was identified as a new microcystin producer. Microcystins [Asp(3)]MC-YR, [Asp(3)] MC-FR, [Asp(3)]MC-HtyR and Ala-Leu/Ile-Asp-Arg-Adda-Glu-Mdha are reported for the first time from the genus Nostoc. All the studied strains were also analyzed for the occurrence of nodularins, cylindrospermopsin and (homo)anatoxin-a, yet no novel producer has been discovered. Our findings indicate rare occurrence of the common cyanotoxins in non-planktic nostocaceae which is in contrast with frequent reports of cyanotoxin producers among phylogenetically closely related planktic cyanobacteria.
Permanent Link: http://hdl.handle.net/11104/0288233