New Membranes with Immobilizing Chiral Selector for Racemic Micture Separation.

0494930 - ÚCHP 2019 CZ eng C - Conference Paper (international conference)
Gaálová, Jana - Cuřínová, Petra - Stibor, Ivan - Izák, Pavel
New Membranes with Immobilizing Chiral Selector for Racemic Micture Separation.
Book of Abstracts. Prague: Czech Membrane Platform, 2018, s. 47, č. článku T1 / SL 04. ISBN 978-80-906831-2-9.
[International Conference on Membrane Processes. Prague (CZ), 13.05.2018-16.05.2018]
R&D Projects: GA ČR(CZ) GA17-00089S
Institutional support: RVO:67985858
Keywords : petraction * racemic mixture * chiral selector membrane
OECD category: Chemical process engineering

Enantiomers exhibit identical properties in the achiral environment, however, they often differ in effectiveness, pharmacological activity and pharmacokinetic profile since the modules with which they interact in biological systems are also optically active [1,2]. Racemic immobilizing chiral selector is present. Five types of membranes with different amount of chiral selector were used. During the pertraction experiments the membranes were subsequently placed between the feed and receiving phase of the pertraction cell. During pertraction experiments we find out, that kinetics of the pertraction significantly influence the enantiomer resolution what indicated that facilitated transport is employed; while enantioselective sorption activity of the membranes reached up to 100%.
Permanent Link: http://hdl.handle.net/11104/0287968