Neuron adhesion on diamond: competition between polymer treatment and surface morphology

0494905 - FZÚ 2019 RIV DE eng J - Journal Article
Jakubcová, B. - Turňová, J. - Řehounek, O. - Polák, J. - Mineva, A. - Taylor, Andrew - Hubík, Pavel - Petrák, V. - Petráková, V.
Neuron adhesion on diamond: competition between polymer treatment and surface morphology.
Advanced Engineering Materials. Roč. 20, č. 9 (2018), s. 1-10, č. článku 1800182. ISSN 1438-1656. E-ISSN 1527-2648
R&D Projects: GA ČR GA17-15319S
Institutional support: RVO:68378271
Keywords : biointerfaces * neural interface * surface treatment * surface morphology * thin diamond film
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 2.906, year: 2018

The ability to form an efficient interface between material and neural cells is a crucial aspect for construction of neuroelectrodes. Diamond offers material characteristics that could, to a large extent, improve the performance of neuroelectrodes. The greatest advantage of diamond is a large variety of material and surface properties such as electrical conductivity, surface morphology, and surface chemistry. Such a variety of material characteristics can lead to various cellular responses. Here, the authors compare survival, adhesion, and neurite formation of primary neurons on diamond thin films of various morphologies and treatments with several types of polymers commonly used to enhance cell adhesion. The authors find that the variation of surface roughness of nanocrystalline diamond film when coated with polymer does not have a major influence on neuron survival or adhesion. The adhesion of neurons can be influenced by the selected type of polymer coating.
Permanent Link: http://hdl.handle.net/11104/0287948