Combined antitumor effect of surface-modified superparamagnetic maghemite nanoparticles and a vitamin E derivative on experimental Walker-256 mammary gland carcinosarcoma

0494217 - ÚMCH 2020 RIV NL eng J - Journal Article
Zasońska, Beata Anna - Pustovyy, V. I. - Babinskiy, A. V. - Palyvoda, O. M. - Chekhun, V. F. - Todor, I. - Petrovský, Eduard - Kuzmenko, O. I. - Horák, Daniel
Combined antitumor effect of surface-modified superparamagnetic maghemite nanoparticles and a vitamin E derivative on experimental Walker-256 mammary gland carcinosarcoma.
Journal of Magnetism and Magnetic Materials. Roč. 471, 1 February (2019), s. 381-387. ISSN 0304-8853. E-ISSN 1873-4766
R&D Projects: GA ČR(CZ) GA17-04918S
Institutional support: RVO:61389013 ; RVO:67985530
Keywords : superparamagnetic * nanoparticles * α-tocopherol
OECD category: Polymer science; Physical geography (GFU-E)
Impact factor: 2.717, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0304885318312216?via%3Dihub

In a search for efficient anti-tumor agent, silica-coated superparamagnetic nanoparticles were designed and used in combination with vitamin E derivative as a potential new tool for anticancer treatment. The particles were characterized by numerous techniques, such as transmission electron microscopy and dynamic light scattering to determine the particle morphology and size both in dry state and water, atomic absorption spectroscopy to analyze the iron content, Fourier-transform infrared spectroscopy to confirm the presence of the functional groups, and vibrating sample magnetometry to determine the magnetic properties and content of maghemite. The next aim was to assess effect of the nanoparticles on suppression of experimental mammary gland carcinosarcoma W-256. Strong antitumor effect was achieved only with combined application of γ-Fe2O3@SiO2 and acetate derivative of α-tocopherol (Toc-6-Ac) resulting in 58% of tumor volume reduction. The results were compared with those obtained with poly(N,N-dimethylacrylamide)-coated iron oxide particles described earlier.
Permanent Link: http://hdl.handle.net/11104/0287706