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Monitoring of enzymatic enantioselective acetylation of gem-difluorinated alcohols by capillary electrophoresis
- 1.0493508 - ÚOCHB 2019 CZ eng C - Conference Paper (international conference)
Šolínová, Veronika - Pomeisl, Karel - Lamatová, Nikola - Pohl, Radek - Brabcová, Jana - Krečmerová, Marcela - Kašička, Václav
Monitoring of enzymatic enantioselective acetylation of gem-difluorinated alcohols by capillary electrophoresis.
Advances in Chromatography and Electrophoresis & Chiranal 2018. Olomouc: Palacký University, 2018 - (Bednář, P.; Cechová, M.; Kučera, L.; Kurka, O.), s. 128-129
[Advances in Chromatography and Electrophoresis & Chiranal 2018. Olomouc (CZ), 29.01.2018-01.02.2018]
R&D Projects: GA ČR(CZ) GA15-01948S; GA ČR(CZ) GA17-10832S
Institutional support: RVO:61388963
Keywords : enantioselective acetylation * difluorinated alcohols * capillary electrophoresis
OECD category: Analytical chemistry
A new fast and highly efficient capillary electrophoretic (CE) method has been developed for chiral analysis of non-charged gem-difluorinated alcohol (3-(benzyloxy)-1,1-difluoro-propan-2-ol) using sulfobutylether-β-CD as chiral selector. The method was applied for monitoring of enzymatic (lipase mediated) enantioselective acetylation of the above alcohol and for determination of enantiomeric purity of both substrates and products of the enzymatic reaction.
Permanent Link: http://hdl.handle.net/11104/0286867
Number of the records: 1