Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury?

0493045 - ÚEM 2019 RIV CN eng J - Journal Article
Růžička, Jiří - Machová-Urdzíková, Lucia - Svobodová, Barbora - Amin, A.G. - Kárová, Kristýna - Dubišová, Jana - Závišková, Kristýna - Kubinová, Šárka - Schmidt, M. - Jhanwar-Uniyal, M. - Jendelová, Pavla
Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury?
Neural Regeneration Research. Roč. 13, č. 1 (2018), s. 119-127. ISSN 1673-5374. E-ISSN 1876-7958
R&D Projects: GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) EF15_003/0000419
Institutional support: RVO:68378041
Keywords : spinal cord injury * epigallocatechin gallate * curcumin * inflammatory response
OECD category: Neurosciences (including psychophysiology
Impact factor: 2.472, year: 2018

Systematic inflammatory response after spinal cord injury is one of the factors leading to lesion development and a profound degree of functional loss. Anti-inflammatory compounds, such as curcumin and epigallocatechin gallate - EGCG are known for their neuroprotective effects. In this study, we investigated the effect of combined therapy of curcumin and EGCG in a rat model of acute SCI induced by balloon compression. Immediately after injury, rats received curcumin, EGCG, curcumin + EGCG or saline. We found that all treatments displayed significant behavioral recovery, with no obvious synergistic effect after combined therapy of curcumin and ECGC. Curcumin and EGCG alone or in combination increased axonal sprouting, decreased glial scar formation, and altered the levels of macrophage inflammatory protein 1-alpha, interleukin-1 beta, interleukin-4 and interleukin-6 cytokines. These results imply that although the expected synergistic response of this combined therapy was less obvious, aspects of tissue regeneration and immune responses in severe spinal cord injury were evident.
Permanent Link: http://hdl.handle.net/11104/0286511