19F magnetic resonance imaging of injectable polymeric implants with multiresponsive behavior

0492562 - ÚMCH 2019 RIV US eng J - Journal Article
Sedláček, Ondřej - Jirák, D. - Gálisová, A. - Jäger, Eliezer - Laaser, J. E. - Lodge, T. P. - Štěpánek, Petr - Hrubý, Martin
19F magnetic resonance imaging of injectable polymeric implants with multiresponsive behavior.
Chemistry of Materials. Roč. 30, č. 15 (2018), s. 4892-4896. ISSN 0897-4756. E-ISSN 1520-5002
R&D Projects: GA ČR(CZ) GA16-03156S
Institutional support: RVO:61389013
Keywords : polymer * 19F magnetic resonance imaging * fluorine
OECD category: Biophysics
Impact factor: 10.159, year: 2018

Recently, magnetic resonance imaging (MRI) probes based on fluorinated compounds have emerged as highly promising contrast agents. Direct imaging of injectable thermoresponsive polymer implants by 19F MRI represents an attractive, as yet unreported tool for the straightforward and non-invasive monitoring of implant localization, size, morphology, and biodegradation. Herein, we describe for the first time the in vivo 19f MRI visualization of such implants. These were subcutaneously and intramuscularly administered as an aqueous solution to form a traceable solid implant upon the change of temperature and pH. After formation, the polymer implant was effectively visualized by 19F MRI. The kinetics of the implant degradation is suitable for application as injectable drug depots or in the local radiotherapy of solid tumors.
Permanent Link: http://hdl.handle.net/11104/0286158