Diabetes, Cardiovascular Disorders and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Body Burden in Czech Patients 50Years After the Intoxication

0492493 - ÚFCH JH 2019 RIV US eng J - Journal Article
Pelcl, T. - Škrha, J. - Prázný, M. - Vlčková, Š. - Fenclová, Z. - Navrátil, Tomáš - Malík, J. - Diblík, P. - Zikán, V. - Pelclová, D.
Diabetes, Cardiovascular Disorders and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Body Burden in Czech Patients 50Years After the Intoxication.
Basic & Clinical Pharmacology & Toxicology. Roč. 123, č. 3 (2018), s. 356-359. ISSN 1742-7835. E-ISSN 1742-7843
Institutional support: RVO:61388955
Keywords : aryl-hydrocarbon receptor * residential proximity * organic pollutants * exposure * workers * dioxin
OECD category: Physical chemistry
Impact factor: 2.452, year: 2018

The correlation between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication and the parameters of metabolic impairment was examined in the last eight male survivors of 80 workers exposed to TCDD during the production of herbicides in a chemical factory in 1965-1967. Their median TCDD blood level was 112 (46-390) pg/g lipids, and the median TCDD body deposit was 3.9 (0.8-11.7) g. This puts these patients into the most severely intoxicated group of subjects, according to back-calculated levels of TCDD. The median TCDD blood level in eight controls was 12pg/g (<0.10 to 22.2pg/g). Markers of metabolic impairment diabetes, dyslipidaemia, arterial hypertension, carotid artery plaque, skin microvascular reactivity, eye fundus hypertensive angiopathy and history of coronary heart disease were assessed and compared to a general male population of comparable age. Measured parameters compared with a population of comparable age were as follows: prevalence of diabetes (62.5% versus 17.6%), arterial hypertension (87.5% versus 71.8%), dyslipidaemia (87.5% versus 88.8%), history of coronary heart disease (62.5% versus 26.0%) and eye fundus hypertension angiopathy (50% versus 14%). All eight patients (100% versus 43%) developed plaques in carotid arteries, six had stenosis >50% and two had a carotid intervention (stenting or endarterectomy). Total cholesterol levels decreased compared to the earlier study this patient group in 2008, most likely due to a more intensive use of lipid-lowering drugs. Several metabolic parameters were higher (diabetes as much as 3.5-fold) in the group of severely TCDD-intoxicated subjects than in a general population of comparable age. This suggests that TCDD plays a role in the development of metabolic impairment and vascular changes.
Permanent Link: http://hdl.handle.net/11104/0286007