Role of adipokinetic hormone during starvation in Drosophila

0492457 - BC 2019 RIV GB eng J - Journal Article
Mochanová, Michaela - Tomčala, Aleš - Svobodová, Zdeňka - Kodrík, Dalibor
Role of adipokinetic hormone during starvation in Drosophila.
Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology. Roč. 226, DEC 01 (2018), s. 26-35. ISSN 1096-4959. E-ISSN 1879-1107
R&D Projects: GA ČR(CZ) GA17-03253S; GA ČR(CZ) GBP501/12/G055
Institutional support: RVO:60077344
Keywords : Drosophila melanogaster mutants * adipokinetic hormone * metabolism
OECD category: Biochemistry and molecular biology
Impact factor: 1.990, year: 2018
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S109649591830099X?via%3Dihub

The role of adipokinetic hormone (AKH) in maintaining the levels of basic nutrients was studied using Drosophila mutants. Our results showed lipids as the main energy reserve, and their physiological level and metabolism were shown to be under the control of AKH. AKH abundance in the body resulted in lower levels of triacylglycerols and diacylglycerols than in the controls, interestingly, there was a disproportional representation of fatty acids in triacylglycerols and diacylglycerols. AKH-deficient flies were more resistant while AKH-abundant flies were more sensitive to starvation, females were found to be more resistant than males probably due to higher body mass and higher amount of nutrients. However, in accordance with the level of all nutrients, that of AKH also gradually decreased with prolonged starvation.
Permanent Link: http://hdl.handle.net/11104/0291444