Nanomaterials in Biomedical research

0491803 - ÚEM 2019 RIV CZ eng M - Monography Chapter
Kárová, Kristýna - Jendelová, Pavla
Glutamate Excitotoxicity in Spinal Cord Injury.
Nanomaterials in Biomedical research. Praha 3: Proxima Tisk, s.r.o., 2017 - (Caraglia, M.), s. 110-116. ISBN 978-80-906655-5-2
R&D Projects: GA MŠMT(CZ) LO1309
Institutional support: RVO:68378041
Keywords : glutamate * NMDA * AMPA * motoneurons
OECD category: Neurosciences (including psychophysiology

Glutamate (glutamic acid) is the most abundant neurotransmitter in the central nervous system and functions as excitatory mediator to trigger depolarizations of postsynaptic neurons. However, in case of excessive amounts of glutamate after injury, prolonged excitation triggers exaggerated pathological neural response, which fuels more damage until it can no longer be metabolically sustained and eventually causes cell death.The role of glutamate excitotoxicity in the spinal cord injury development is discussed in the article.
Permanent Link: http://hdl.handle.net/11104/0285827