Laser-synthesized nanocrystalline, ferroelectric, bioactive BaTiO.sub.3./sub./Pt/FS for bone implants

0490265 - FZÚ 2019 RIV GB eng J - Journal Article
Jelínek, Miroslav - Buixaderas, Elena - Drahokoupil, Jan - Kocourek, Tomáš - Remsa, Jan - Vaněk, Přemysl - Vandrovcová, Marta - Doubková, Martina - Bačáková, Lucie
Laser-synthesized nanocrystalline, ferroelectric, bioactive BaTiO₃/Pt/FS for bone implants.
Journal of Biomaterials Applications. Roč. 32, č. 10 (2018), s. 1464-1475. ISSN 0885-3282. E-ISSN 1530-8022
R&D Projects: GA ČR(CZ) GA15-01558S
Institutional support: RVO:68378271 ; RVO:67985823
Keywords : BaTiO₃ * pulsed laser deposition * biotests * ferroelectricity * implants
OECD category: Condensed matter physics (including formerly solid state physics, supercond.); Physical chemistry (FGU-C)
Impact factor: 2.442, year: 2018

The goal of our study is to design BaTiO3 ferroelectric layers that will cover metal implants and provide improved osseointegration. We synthesized ferroelectric BaTiO3 layers on Pt/fused silica substrates, and we studied their physical and bio-properties. BaTiO3 and Pt layers were prepared using KrF excimer laser ablation at substrate temperature T-s in the range from 200 degrees C to 750 degrees C in vacuum or under oxygen pressure of 10 Pa, 15 Pa, and 20 Pa. The BaTiO3/Pt and Pt layers adhered well to the substrates. BaTiO3 films of crystallite size 60-140 nm were fabricated. Ferroelectric loops were measured and ferroelectricity was also confirmed using Raman scattering measurements. Results of atomic force microscopy topology and the X-ray diffraction structure of the BaTiO3/Pt/fused silica multilayers are presented. The adhesion, viability, growth, and osteogenic differentiation of human osteoblast-like Saos-2 cells were also studied. On days 1, 3, and 7 after seeding, the lowest cell numbers were found on non-ferroelectric BaTiO3, while the values on ferroelectric BaTiO3, on non-annealed and annealed Pt interlayers, and on the control tissue culture polystyrene dishes and microscopic glass slides were similar, and were usually significantly higher than on non-ferroelectric BaTiO3.
Permanent Link: http://hdl.handle.net/11104/0284528