Phosphatidylglycerol is implicated in divisome formation and metabolic processes of cyanobacteria

0490008 - MBÚ 2019 RIV DE eng J - Journal Article
Kobori, T.O. - Uzumaki, T. - Kis, M. - Kovacs, L. - Domonkos, I. - Itoh, S. - Krynická, Vendula - Kuppusamy, S.G. - Zakar, T. - Dean, Jason Lawrence - Szilák, L. - Komenda, Josef - Gombos, Z. - Ughy, B.
Phosphatidylglycerol is implicated in divisome formation and metabolic processes of cyanobacteria.
Journal of Plant Physiology. Roč. 223, APR2018 (2018), s. 96-104. ISSN 0176-1617. E-ISSN 1618-1328
R&D Projects: GA MŠMT(CZ) LO1416
Institutional support: RVO:61388971
Keywords : Division * Electron transport * Phosphatidylglycerol
OECD category: Microbiology
Impact factor: 2.825, year: 2018

Phosphatidylglycerol is an essential phospholipid for photosynthesis and other cellular processes. We investigated the role of phosphatidylglycerol in cell division and metabolism in a phophatidylglycerol-auxotrophic strain of Synechococcus PCC7942. Here we show that phosphatidylglycerol is essential for the photosynthetic electron transfer and for the oligomerisation of the photosynthetic complexes, notably, we revealed that this lipid is important for non-linear electron transport. Furthermore, we demonstrate that phosphatidylglycerol starvation elevated the expressions of proteins of nitrogen and carbon metabolism. Moreover, we show that phosphatidylglycerol-deficient cells changed the morphology, became elongated, the FtsZ ring did not assemble correctly, and subsequently the division was hindered. However, supplementation with phosphatidylglycerol restored the ring-like structure at the mid-cell region and the normal cell size, demonstrating the phosphatidylglycerol is needed for normal septum formation. Taken together, central roles of phosphatidylglycerol were revealed, it is implicated in the photosynthetic activity, the metabolism and the fission of bacteria.
Permanent Link: http://hdl.handle.net/11104/0284305