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Spatial navigation deficits in amnestic mild cognitive impairment with neuropsychiatric comorbidity

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    0489956 - FGÚ 2019 RIV GB eng J - Journal Article
    Keynejad, R. C. - Marková, H. - Šiffelová, K. - Kumar, N. - Vlček, Kamil - Laczó, J. - Migo, E. M. - Hort, J. - Kopelman, M. D.
    Spatial navigation deficits in amnestic mild cognitive impairment with neuropsychiatric comorbidity.
    Aging Neuropsychology and Cognition. Roč. 25, č. 2 (2018), s. 277-289. ISSN 1382-5585. E-ISSN 1744-4128
    Institutional support: RVO:67985823
    Keywords : mild cognitive impairment * neuropsychiatric comorbidity * spatial navigation * spatial memory
    OECD category: Neurosciences (including psychophysiology
    Impact factor: 1.919, year: 2018

    To find out whether neuropsychiatric comorbidity (comMCI) influences spatial navigation performance in amnestic mild cognitive impairment (aMCI).Methods: We recruited aMCI patients with (n=21) and without (n=21) neuropsychiatric comorbidity or alcohol abuse, matched for global cognitive impairment and cognitively healthy elderly participants (HE, n=22). They completed the Mini-Mental State Examination and a virtual Hidden Goal Task in egocentric, allocentric, and delayed recall subtests.Results: In allocentric navigation, aMCI and comMCI performed significantly worse than HE and similarly to each other. Although aMCI performed significantly worse at egocentric navigation than HE, they performed significantly better than patients with comMCI.Conclusions: Despite the growing burden of dementia and the prevalence of neuropsychiatric symptoms in the elderly population, comMCI remains under-studied. Since trials often assess pure aMCI, we may underestimate patients' navigation and other deficits. This finding emphasizes the importance of taking account of the cognitive effects of psychiatric disorders in aMCI.
    Permanent Link: http://hdl.handle.net/11104/0284250

     
     
Number of the records: 1  

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