Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine.

0489341 - FGÚ 2019 RIV US eng J - Journal Article
Szczurowska, E. - Ahuja, Nikhil - Jiruška, Přemysl - Kelemen, E. - Stuchlík, Aleš
Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine.
Progress in Neuro-Psychopharmacology & Biological Psychiatry. Roč. 81, Feb 2 (2018), s. 275-283. ISSN 0278-5846. E-ISSN 1878-4216
R&D Projects: GA ČR(CZ) GA17-04047S
Institutional support: RVO:67985823
Keywords : psychosis * MK-801 * neuronal discoordination * hippocampus * Theta rhythm
OECD category: Neurosciences (including psychophysiology
Impact factor: 4.315, year: 2018

The discoordination hypothesis of schizophrenia posits discoordination of neural activity as the central mechanism that underlies some psychotic symptoms (including 'hallmark' cognitive symptoms) of schizophrenia. To test this proposition, we studied the activity of hippocampal neurons in urethane anesthetized Long Evans rats after 0.15 mg/kg dizocilpine (MK-801), an N-Methyl-D-aspartate (NMDA) glutamate receptor antagonist, which can cause psychotic symptoms in humans and cognitive control impairments in animals. We observed that MK-801 altered the temporal coordination, but not rate, of neuronal firing. Coactivation between neurons increased, driven primarily by increased coincident firing of cell pairs that did not originally fire together before MK-801 injection. Increased pairwise coactivation manifested as disorganized discharge on the level of neuronal ensembles, which in turn could lead to disorganization in information processing. Disorganization of neuronal activity after a psychotomimetic dose of MK-801 supports the discoordination hypothesis of psychosis.
Permanent Link: http://hdl.handle.net/11104/0283778