Commentary: Baseline adiponectin concentration and clinical outcomes among patients with diabetes and recent acute coronary syndrome in the EXAMINE trial

0488920 - ÚI 2019 CH eng J - Journal Article
Brož, J. - Brabec, Marek - Kvapil, M. - Polák, J.
Commentary: Baseline adiponectin concentration and clinical outcomes among patients with diabetes and recent acute coronary syndrome in the EXAMINE trial.
Frontiers in Endocrinology. Roč. 9, April (2018), č. článku 138. ISSN 1664-2392. E-ISSN 1664-2392
Institutional support: RVO:67985807
Keywords : adiponectin * type 2 diabetes mellitus * cardiovascular risk * acute coronary syndrome * all-cause mortality rate
OECD category: Endocrinology and metabolism (including diabetes, hormones)
Impact factor: 3.634, year: 2018

Bergmark et al. published a study dealing with the relationship of cardiovascular (CV) risks and adiponectin levels (1). The paper analyses the plasma levels of adiponectin in acute coronary syndrome type 2 diabetes patients (ACS) enrolled in the study EXAMINE (alogliptin vs. placebo, adiponectin sampled at study baseline) where they were monitored for CV outcomes (but not adiponectin) for a period of 18 months (2). Bergmark et al. conclude that adiponectin concentration was independently positively associated with increased risk of death from CV causes, all-cause mortality, and hospitalization for heart failure. In the introduction and the discussion, the authors mention that the relation between the adiponectin level and CV outcomes has been investigated in several studies, nevertheless with heterogeneous results: in some of them, adiponectin is associated with an increased CV risk, while others conclude that it is a protective factor. This study results rank adiponectin among factors that may increase CV risk in ACS type 2 diabetes patients. Despite the fact that the evaluation and discussion in the paper of Bergmark et al. is very complex, we would like to respectfully address the authors with at least two comments which we consider important.
Permanent Link: http://hdl.handle.net/11104/0283432