Anthracycline antibiotics derivate mitoxantrone-Destructive sorption and photocatalytic degradation

0488747 - ÚACH 2019 RIV US eng J - Journal Article
Štenglová Netíková, I. R. - Petruželka, L. - Šťastný, Martin - Štengl, Václav
Anthracycline antibiotics derivate mitoxantrone-Destructive sorption and photocatalytic degradation.
PLoS ONE. Roč. 13, č. 3 (2018), č. článku e0193116. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA TA ČR(CZ) TG02010049
Institutional support: RVO:61388980
Keywords : anthracycline antibiotics derivate * nanostructured titanium(IV) oxide
OECD category: Inorganic and nuclear chemistry
Impact factor: 2.776, year: 2018

Nanostructured titanium(IV) oxide was used for the destructive adsorption and photocatalytic degradation of mitoxantrone (MTX), a cytostatic drug from the group of anthracycline antibiotics. During adsorption on atitania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1, 4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl) amino)-8-((2-(methylamino)ethyl)amino)anthracene-9, 10-dione, 1, 4-dihydroxy-5, 8-diimi-noanthracene-9, 10(5H, 8H)-dione and 1, 4-dihydroxy-5-imino-8-(methyleneamino)anthra-cene-9, 10(5H, 8H)-dione, were identified. In the case of photocatalytic degradation, only one degradation product after 15 min at m/z 472 was identified. This degradation product corresponded to mitoxantrone dicarboxylic acid, and complete mineralization was attained in one hour. Destructive adsorbent manganese(IV) oxide, MnO 2 , was used only for the destructive adsorption of MTX. Destructive adsorption occurred only for one degradation product, mitoxantrone dicarboxylic acid, against anatase TiO 2 .
Permanent Link: http://hdl.handle.net/11104/0283287