Number of the records: 1
Role of FoF1 ATP Synthase and its inhibitory peptide IF1 in both life stages of Trypanosoma brucei
- 1.0488335 - BC 2018 RIV CZ eng O - Others
Zíková, Alena - Panicucci, Brian - Gahura, Ondřej
Role of FoF1 ATP Synthase and its inhibitory peptide IF1 in both life stages of Trypanosoma brucei.
2017
R&D Projects: GA MŠMT LL1205
Institutional support: RVO:60077344
Keywords : IF1 * ATP synthase * T. brucei
OECD category: Biochemistry and molecular biology
During hypoxia aerobic eukaryotes protect themselves against deleterious ATP depletion caused by the reversal of mitochondrial (mt) ATP synthase activity to ATP hydrolysis, which is inevitable consequence of the mt membrane potential (m) collapse in the lack of oxygen. The protection involves IF1, a protein inhibiting ATP hydrolysis by reversible binding to F1-ATPase, the catalytic sector of the enzyme.
Permanent Link: http://hdl.handle.net/11104/0282921
Number of the records: 1