Study of the production yields of .sup.18./sup.F, .sup.11./sup.C, .sup.13./sup.N and .sup.15./sup.O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals

0488129 - FZÚ 2018 RIV NL eng J - Journal Article
Amato, E. - Italiano, A. - Margarone, Daniele - Pagano, B. - Baldari, S. - Korn, Georg
Study of the production yields of ¹⁸F, ¹¹C, ¹³N and ¹⁵O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals.
Nuclear Instruments & Methods in Physics Research Section A. Roč. 811, Mar (2016), s. 1-5. ISSN 0168-9002. E-ISSN 1872-9576
R&D Projects: GA MŠMT ED1.1.00/02.0061; GA MŠMT EF15_008/0000162
Grant - others:ELI Beamlines(XE) CZ.1.05/1.1.00/02.0061; ELI Beamlines(XE) CZ.02.1.01/0.0/0.0/15_008/0000162
Institutional support: RVO:68378271
Keywords : plasma laser * proton acceleration * positron emission tomography * microfluidics
OECD category: Fluids and plasma physics (including surface physics)
Impact factor: 1.362, year: 2016

The development of novel compact PET radionuclide production systems is of great interest to promote the diffusion of PET diagnostics, especially in view of the continuous development of microfluidics labeling approaches. We studied the feasibility to produce clinically-relevant amounts of PET isotopes by means of laser-accelerated proton sources such that expected at the ELI-Beamlines facility. F-18, C-11, N-13 and O-15 production yields were calculated through the TALYS software, by taking into account the broad proton spectra expected. With the hypothesized proton fluencies, clinically-relevant amounts of radionuclides can be obtained, suitable to prepare single doses of F-18-, C-11- and N-13-labeled radio pharmaceuticals exploiting fast and efficient microfluidic labeling systems.
Permanent Link: http://hdl.handle.net/11104/0282748