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G-Protein-Coupled Receptor Dimers
- 1.0487911 - ÚMG 2018 RIV CH eng M - Monography Chapter
Blahoš, Jaroslav
Metabotropic Glutamate Receptors.
G-Protein-Coupled Receptor Dimers. Cham: Springer Nature, 2017 - (Di Giovanni, G.), s. 327-357. ISBN 978-3-319-60172-4
R&D Projects: GA ČR GAP303/12/2408
Institutional support: RVO:68378050
Keywords : dimerization * GPCR * metabotropic glutamate receptors
OECD category: Neurosciences (including psychophysiology
Metabotropic Glutamate receptors (mGluRs) belong to Family C GPCRs.The mGluRs are putative dimers, both homodimers and, as revealed recently, also heterodimers. The heterodimerization may occur between different receptors (e.g. mGluR1/5, mGluR2/3), but also between splice variants resulting from alternative transcription of one gene (mGluR1a/b). This leads to previously unexpected diversity both physiologically, and potentially pharmacologically.
Permanent Link: http://hdl.handle.net/11104/0282517
Number of the records: 1