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Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes
- 1.0487732 - UFCH-W 2019 RIV US eng J - Journal Article
Kulig, W. - Mikkolainen, H. - Olžyńska, Agnieszka - Jurkiewicz, Piotr - Cwiklik, Lukasz - Hof, Martin - Vattulainen, I. - Jungwirth, P. - Rog, T.
Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes.
Journal of Physical Chemistry Letters. Roč. 9, č. 5 (2018), s. 1118-1123. ISSN 1948-7185
R&D Projects: GA ČR(CZ) GBP208/12/G016; GA MŠk(CZ) EF16_019/0000729
Institutional support: RVO:61388955
Keywords : biological membranes * alcohols * cell membranes
Subject RIV: CF - Physical ; Theoretical Chemistry
OBOR OECD: Physical chemistry
Impact factor: 8.709, year: 2017
Translocation of sterols between cellular membrane leaflets is of key importance in membrane organization, dynamics, and signaling. We present a novel translocation mechanism that differs in a unique manner from the established ones. The bobbing mechanism identified here is demonstrated for tail-oxidized sterols, but is expected to be viable for any molecule containing two polar centers at the opposite sides of the molecule. The mechanism renders translocation across a lipid membrane possible without a change in molecular orientation. For tail-oxidized sterols, the bobbing mechanism provides an exceptionally facile means to translocate these signaling molecules across membrane structures and may thus represent an important pathway in the course of their biological action.
Permanent Link: http://hdl.handle.net/11104/0282365